Mackenzie, Ian
Professor, Dept of Pathology and Laboratory Medicine
MD (1984) University of Western Ontario
FRCPC, Neuropathology (1989) Royal College of Physicians and Surgeons of Canada
Research Interests
General:
Pathological basis of dementia syndromes and movement disorders.
Specific projects:
Clinical, pathological and genetic correlation of frontotemporal dementia and dementia in motor neuron disease.
Clinical, anatomical, pathological correlation in Parkinson's disease and Lewy body dementia.
Pathological correlate of "mild cognitive impairment".
Etiological studies on Parkinson's disease.
Immune mechanisms and microglial activation in neurodegenerative disorders.
Selected Publications
Mackenzie IRA, Hao C, Munoz DG. 1995. The role of microglia in senile plaque formation. Neurobiol Aging 16:797-804
Mackenzie IRA, McLachlan RS, Kubu C, Miller LA. 1996. Prospective neuropsychological assessment of nondemented patients with biopsy proven senile plaques. Neurology 46:425-429
Mackenzie IRA, Munoz DG. 1998. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology 50:986-990
Mackenzie IRA, Feldman H.The relationship between extramotor ubiquitin-immunoreactive neuronal inclusions and dementia in motor neuron disease. Acta Neuropathol 2003; 105:98-102.
Mackenzie IRA, Feldman H. Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases. Acta Neuropathol 2003; 105:543-548.